Ok, your question is a bit vague but I think you want to know what buffer to use for duo, SE or Prophet.
My guess would be that these days with pots dropping everywhere a Prophet would be better. You won't have trouble keeping your HP up. If you want to go to necro's/catacombs then a SE will be better since they got vr and you can get haste from pots.
i would say the best for a th is a PP zerk ,might ,greater might, focus, Death whisper,haste, ww, gadince
u really dont need a se really they more for nukers or polers yes they nice but ur pp can heal u fine without have to us to much mana up and u can have so pots just in case