I am currently a lvl 63 SH and was curious on what the -8 men when using +4 int and wit tats effects mana during pve, I don't like sitting/standing to much lol.
The only thing that you need to worry about when decreasing your Men, is that it makes it very easy to land debuff on you. The lower your Men, the more often anchor, silence, slow, hex, and other debuffs will land on you.
But normally the faster u cast, the less u have to worry about dangerous debuffs
simple debuffs cast in like what? .2 seconds? the problamatic debuffs like vhaidren said anchor/silence, take a bit longer to cast which means the faster cast speed u have over your oppenent the lesser chance u have of getting debuffed as either u will cancel through nukes or silence before u get hit